By Graca Soveral,Soren Nielsen,Angela Casini
Since the invention of Aquaporin-1 (AQP1) as a water channel, many reviews have printed the significance of aquaporins in mammalian body structure and pathophysiology in addition to plant and microbial biology. The reports have additionally proven aquaporins as power drug ambitions and objectives for bettering crop properties.
Written by means of a world team of individuals on the leading edge of the sphere, Aquaporins in well-being and ailment: New Molecular ambitions for Drug Discovery offers the newest examine advances in aquaporins and different significant intrinsic protein (MIP) channels. the 1st portion of the ebook describes the overall techniques of aquaporin channel functionality, genomic examine, structure-function research of aquaporins and glycerol facilitators, and legislation by means of gating and trafficking, together with yeast aquaporin legislation and serve as. the second one part discusses the physiological and pathophysiological roles of aquaporins in people and microbes. the ultimate part covers the advance of inhibitors of aquaporin functionality. The book’s epilogue bargains destiny views and instructions, frequently within the sector of aquaporin-based diagnostics and therapeutics.
Stimulating destiny learn in this vital protein family members, this publication allows a paradigm shift within the knowing and roles of aquaporin membrane proteins in all organic settings. It encourages scientists to improve novel methods for the therapy of human illnesses in line with aquaporin functionality or dysfunction.
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Extra info for Aquaporins in Health and Disease: New Molecular Targets for Drug Discovery
Aquaporins in Health and Disease: New Molecular Targets for Drug Discovery by Graca Soveral,Soren Nielsen,Angela Casini